Median age was 65.5 years and most patients were females monoclonal paraprotein was IgG in 92%. In this review, we analysed data from 17 such cases reported between 19. However, an acute bacterial infection is rarely reported as the first manifestation of underlying MM. Gram-positive infections, mainly pneumonia from Streptococcus pneumoniae, occur more frequently in patients with untreated disease while Gram-negative infections, mainly of the urinary tract, are more common after chemotherapy. The propensity to infection is increased in the first months after the initial diagnosis and in patients with renal dysfunction. This is called a haploidentical (or half-matched) transplant.Increased susceptibility to bacterial infections is a common manifestation of multiple myeloma (MM), arising mainly from a defect in humoral immunity and is associated with major morbidity and mortality. For some patients, a donor who matches exactly half of their HLA is best. There are times when a closely matched donor isn’t the best option. GVHD happens when the immune cells from the donated cells (the graft) attack the recipient’s cells (the host). Reduces the risk of complications like graft-versus-host disease (GVHD).Helps your donor cells engraft (grow and make new blood cells in your body).Improves the chances for a successful transplant.Usually, it’s a donor or CBU whose HLA are very closely matched to yours. Your doctor wants to find the best possible donor or CBU for you. Email: you are a hematologist or oncologist who would like to learn more about our HLA Today program, visit /HLAToday or email us at Why is finding the best donor or cord blood unit (CBU) important?.If you haven't been to a transplant center yet, your doctor can test your HLA type for free through our HLA Today program.Ĭontact our Patient Support Center with any questions: You’re more likely to match someone with a similar ethnic background or ancestry. Each of your brothers and sisters who has the same mom and dad as you has a 1 in 4 chance (25%) ofīeing a complete, or full, match. HLA types are inherited so siblings can sometimes be a match for each other. Sometimes, it’s hard to find a match because some HLA types are less common. The names are letters or combinations of letters and numbers. Your doctor will decide which donor has the best HLA match for you. Your HLA type will be compared to potential donors to see if there is a match.The blood or cheek swab is tested in a lab to figure out your HLA type.You and potential donors will have blood drawn or will have the inside of your cheek swabbed.It's much more complicated than blood typing. If 2 people share the same HLA type, they are considered a 'match'. HLA matching is used to match patients and donors for blood or marrow transplants.
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